ABSTRACT
OBJECTIVE:To study the improvement effect of geniposide on cognitive dysfunction in model rats with diabetes. METHODS:50 rats were randomly divided into blank control group(distilled water),model group(distilled water)and genipo-side low-dose,medium-dose,high-dose groups(5,10,20 g/kg),10 in each group. Except for blank control group,rats in other 4 groups were fed with high-sugar and high-fat diet and injected streptozotocin to induce diabetes model. After modeling,rats in each group intragastrically administrated relevant medicines,once a day,for 8 weeks. After last administration,fasting blood glu-cose(FPG),glycosylated hemoglobin(HbA1c)levels,escape latency period in Morris water maze test,and correct rate of behav-iors in Y maze test of rats in each group were detected. RESULTS:Compared with blank control group,FPG,HbA1c levels of rats in model group were obviously increased,escape latency period was obviously prolonged,correct rate of behaviors in Y maze test was obviously decreased,with statistical significances(P<0.05). Compared with model group,above-mentioned indexes in genipo-side groups were obviously improved(P<0.05),which were positively correlated with dose(P<0.05). CONCLUSIONS:Genipo-side can effectively reduce blood glucose level of model rats with diabetes and improve their cognitive dysfunction.